NudT16: Difference between revisions
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Iyama et. al. determined that NudT16 is a (Deoxy)inosine diphosphatase and that the loss of this protein is followed by increased accumulation of single-strand breaks in DNA, reduced proliferation, and increased cell arrest. They also found increased levels of inosine in RNA, which informed the conclusion that HsNudT16 functions in the nucleus to protect the cell from ITP and its detrimental effects <ref>PMID:20385596</ref> . | Iyama et. al. determined that NudT16 is a (Deoxy)inosine diphosphatase and that the loss of this protein is followed by increased accumulation of single-strand breaks in DNA, reduced proliferation, and increased cell arrest. They also found increased levels of inosine in RNA, which informed the conclusion that HsNudT16 functions in the nucleus to protect the cell from ITP and its detrimental effects <ref>PMID:20385596</ref> . | ||
== References == | == References == | ||
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