1dpj: Difference between revisions

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[[Image:1dpj.gif|left|200px]]
{{Seed}}
[[Image:1dpj.png|left|200px]]


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{{STRUCTURE_1dpj|  PDB=1dpj  |  SCENE=  }}  
{{STRUCTURE_1dpj|  PDB=1dpj  |  SCENE=  }}  


'''THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR'''
===THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR===




==Overview==
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Aspartic proteinase A from yeast is specifically and potently inhibited by a small protein called IA3 from Saccharomyces cerevisiae. Although this inhibitor consists of 68 residues, we show that the inhibitory activity resides within the N-terminal half of the molecule. Structures solved at 2.2 and 1.8 A, respectively, for complexes of proteinase A with full-length IA3 and with a truncated form consisting only of residues 2-34, reveal an unprecedented mode of inhibitor-enzyme interactions. Neither form of the free inhibitor has detectable intrinsic secondary structure in solution. However, upon contact with the enzyme, residues 2-32 become ordered and adopt a near-perfect alpha-helical conformation. Thus, the proteinase acts as a folding template, stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.
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{{ABSTRACT_PUBMED_10655612}}


==About this Structure==
==About this Structure==
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[[Category: Ia3 peptide]]
[[Category: Ia3 peptide]]
[[Category: Proteinase some]]
[[Category: Proteinase some]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:07:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:25:19 2008''

Revision as of 20:25, 30 June 2008

File:1dpj.png

Template:STRUCTURE 1dpj

THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR

Template:ABSTRACT PUBMED 10655612

About this Structure

1DPJ is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix., Li M, Phylip LH, Lees WE, Winther JR, Dunn BM, Wlodawer A, Kay J, Gustchina A, Nat Struct Biol. 2000 Feb;7(2):113-7. PMID:10655612

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