1dpk: Difference between revisions

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[[Image:1dpk.jpg|left|200px]]
{{Seed}}
[[Image:1dpk.png|left|200px]]


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{{STRUCTURE_1dpk|  PDB=1dpk  |  SCENE=  }}  
{{STRUCTURE_1dpk|  PDB=1dpk  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE INTEGRIN ALPHA-IIB SUBUNIT'''
===SOLUTION STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE INTEGRIN ALPHA-IIB SUBUNIT===




==Overview==
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A key step in the activation of heterodimeric integrin adhesion receptors is the transmission of an agonist-induced cellular signal from the short alpha- and/or beta-cytoplasmic tails to the extracellular domains of the receptor. The structural details of how the cytoplasmic tails mediate such an inside-out signaling process remain unclear. We report herein the NMR structures of a membrane-anchored cytoplasmic tail of the alpha(IIb)-subunit and of a mutant alpha(IIb)-cytoplasmic tail that renders platelet integrin alpha(IIb)beta(3) constitutively active. The structure of the wild-type alpha(IIb)-cytoplasmic tail reveals a "closed" conformation where the highly conserved N-terminal membrane-proximal region forms an alpha-helix followed by a turn, and the acidic C-terminal loop interacts with the N-terminal helix. The structure of the active mutant is significantly different, having an "open" conformation where the interactions between the N-terminal helix and C-terminal region are abolished. Consistent with these structural differences, the two peptides differ in function: the wild-type peptide suppressed alpha(IIb)beta(3) activation, whereas the mutant peptide did not. These results provide an atomic explanation for extensive biochemical/mutational data and support a conformation-based "on/off switch" model for integrin activation.
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{{ABSTRACT_PUBMED_10677482}}


==About this Structure==
==About this Structure==
1DPK is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPK OCA].  
1DPK is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPK OCA].  


==Reference==
==Reference==
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[[Category: Vinogradova, O.]]
[[Category: Vinogradova, O.]]
[[Category: Helix-turn]]
[[Category: Helix-turn]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:07:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:25:28 2008''

Revision as of 20:25, 30 June 2008

File:1dpk.png

Template:STRUCTURE 1dpk

SOLUTION STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE INTEGRIN ALPHA-IIB SUBUNIT

Template:ABSTRACT PUBMED 10677482

About this Structure

1DPK is a Single protein structure. Full experimental information is available from OCA.

Reference

A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit., Vinogradova O, Haas T, Plow EF, Qin J, Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1450-5. PMID:10677482

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