2ce8: Difference between revisions
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<StructureSection load='2ce8' size='340' side='right'caption='[[2ce8]], [[Resolution|resolution]] 2.03Å' scene=''> | <StructureSection load='2ce8' size='340' side='right'caption='[[2ce8]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ce8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ce8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CE8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ce8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ce8 OCA], [https://pdbe.org/2ce8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ce8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ce8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ce8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ce8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ce8 OCA], [https://pdbe.org/2ce8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ce8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ce8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ce8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pearl | [[Category: Pearl LH]] | ||
[[Category: Pickles | [[Category: Pickles LM]] | ||
[[Category: Roe | [[Category: Roe SM]] | ||
