Protein Hfq

spinqualitylabelsall models Structure of human pentameric SAP (green, grey, pink, yellow, magenta) complex with AMP and Ca+2 ions (green) (PDB code 4ht9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Protein Hfq (Hfq) (Host Factor for Qβ) or RNA-binding protein Hfq is stimulating base-pairing between sRNA and target mRNA by binding both RNAs via three RNA-binding surfaces. Hfq is found in enteric bacteria. SAP binds in a calcium-dependent fashion to a variety of ligands. Relevance Since Hfq is required for gene regulation and infectivity of some Gram-negative bacteria its mutations can eliminate infectivity of Lyme disease caused by the bacteria Borellia burgdorferi, for example. Structural highlights The 3D structure of a complex of SAP with the small molecule ligand AMP shows the nucleotide phosphate group bridging two Ca+2 ions and forming hydrogen bonds to Asn, Gln and Try residues of SAP .

3D Structures of protein Hfq

Updated on 22-February-2021

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• Protein Hfq
  • 1hk9, 2y90, 2yht, 3qhs, 4rcb, 4rcc, 6bdg – EcHfq – Escherichia coli
    
  • 4jli, 4jri, 4jrk, 4juv – EcHfq (mutant)
    
  • 1u1s, 1u1t, 4j6y, 6xyj – PaHfq – Pseudomonas aeruginosa
    
  • 3inz, 3m4g, 4mml, 4mmk, 5i21 – PaHfq (mutant)
    
  • 2ylb – StHfq – Salmonella typhimurium
    
  • 6gwk – Hfq – Caulobacter crescentus
    
  • 4nl2 – LmHfq – Listeria monocytogenes
    
  • 4noy – LmHfq (mutant)
    
  • 5szd – AaHfq – Aquifex aeolicus
    
  • 3sb2 – Hfq - Herbaspirillum seropedicae
    
  • 1kq1 – SaHfq – Staphylococcus aureus
    
  • 2qtx, 4x9c – MjHfq – Methanococcus jannaschii
    
  • 3hfn – Hfq - Anabaena
    
• Protein Hfq complex with nucleotide
  • 3res – EcHfq + ADP
    
  • 3qo3 – EcHfq + ATP
    
  • 4pno – EcHfq + UMP
    
  • 4j6x – PaHfq + UTP
    
  • 3qui – PaHfq + ADPNP
    
  • 4j5y – PaHfq + ATP
    
  • 4j6w – PaHfq + CTP
    
  • 2ylc – StHfq + UMP
    
  • 5dy9 – MjHfq (mutant) + AMP
    
  • 4x9d – MjHfq + UMP
    
• Protein Hfq other complexes
  • 6qlb – EcHfq + calpain
    
  • 3vu3 – EcHfq + catalase
    
  • 3gib, 4ht8 – EcHfq + poly(A)
    
  • 4ht9, 5new – EcHfq + poly(A) + poly(U)
    
  • 3rer – EcHfq + poly(U) + ADP
    
  • 4qvc, 4qvd – EcHfq + RNA
    
  • 5uk7 – EcHfq + DNA
    
  • 3ahu, 3hsb – Hfq + RNA – Bacillus subtilis
    
  • 6o1k, 6o1l, 6o1m – PaHfq + Crc + RNA – Cryo EM
    
  • 4v2s – StHfq + sRNA
    
  • 4y91 – Hfq + poly(U) – Thermotoga maritima
    
  • 4nl3 – LmHfq + poly(U)
    
  • 5sze – AaHfq + poly(U)
    
  • 1kq2 – SaHfq + RNA
    

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Michal Harel, Alexander Berchansky