6lzz: Difference between revisions
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==Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a== | ==Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a== | ||
<StructureSection load='6lzz' size='340' side='right'caption='[[6lzz]]' scene=''> | <StructureSection load='6lzz' size='340' side='right'caption='[[6lzz]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[6lzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZZ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzz OCA], [https://pdbe.org/6lzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzz RCSB], [https://www.ebi.ac.uk/pdbsum/6lzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzz ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4000375Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EZU:1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one'>EZU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzz OCA], [https://pdbe.org/6lzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzz RCSB], [https://www.ebi.ac.uk/pdbsum/6lzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzz ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref> | |||
==See Also== | |||
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Huang YY]] | [[Category: Huang YY]] | ||
[[Category: Luo HB]] | [[Category: Luo HB]] | ||
[[Category: Wu Y]] | [[Category: Wu Y]] | ||
