1dsl: Difference between revisions

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[[Image:1dsl.gif|left|200px]]
{{Seed}}
[[Image:1dsl.png|left|200px]]


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{{STRUCTURE_1dsl|  PDB=1dsl  |  SCENE=  }}  
{{STRUCTURE_1dsl|  PDB=1dsl  |  SCENE=  }}  


'''GAMMA B CRYSTALLIN C-TERMINAL DOMAIN'''
===GAMMA B CRYSTALLIN C-TERMINAL DOMAIN===




==Overview==
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We use protein engineering and crystallography to simulate aspects of the early evolution of beta gamma-crystallins by observing how a single domain oligomerizes in response to changes in a sequence extension. The crystal structure of the C-terminal domain of gamma beta-crystallin with its four-residue C-terminal extension shows that the domain does not form a symmetric homodimer analogous to the two-domain pairing in beta gamma-crystallins. Instead the C-terminal extension now forms heterologous interactions with other domains leading to the solvent exposure of the natural hydrophobic interface with a consequent loss in protein solubility. However, this domain truncated by just the C-terminal tyrosine forms a symmetric homodimer of domains in the crystal lattice.
The line below this paragraph, {{ABSTRACT_PUBMED_8605629}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8605629 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8605629}}


==About this Structure==
==About this Structure==
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[[Category: Eye lens protein]]
[[Category: Eye lens protein]]
[[Category: Multigene family]]
[[Category: Multigene family]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:13:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:33:11 2008''
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