Sandbox GGC7: Difference between revisions

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==Iduronate 2-sulfatase==

~~This~~ is a ~~default text for your page. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~

Iduronate 2-sulfatase (I2S), also referred to as Alpha-L-iduronate sulfate sulfatase or Idursulfase, is a lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.[1]

~~You may include any references to papers as~~ in: the ~~use~~ of ~~JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue~~.

[[Image:MW_Folding_Simulations.gif]]

== Function ==

Iduronate 2-sulfatase is involved in the degradation pathway of dermatan sulfate and heparan sulfate. It hydrolyzes the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. ~~It also binds~~ 1 ~~Ca2+ ion per subunit~~.

Iduronate 2-sulfatase is located in the lysosome.[1] It is involved in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.[1] I2S hydrolyzes the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.[1] Dermatan sulfate and heparan sulfate are complex glycosaminoglycans, which are essentially large sugar molecules.[2] They play important roles in cell adhesion, growth, proliferation and repair, and their degradation and recycling in the lysosome are essential for cellular maintenance.[2]

== Relevance ==

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 ==Iduronate 2-sulfatase==
 <StructureSection load='5FQL' size='340' side='right' caption='Iduronate 2-sulfatase protein' scene=''>
-This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+Iduronate 2-sulfatase (I2S), also referred to as Alpha-L-iduronate sulfate sulfatase or Idursulfase, is a lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.[1]
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 [[Image:MW_Folding_Simulations.gif]]
 == Function ==
-Iduronate 2-sulfatase is involved in the degradation pathway of dermatan sulfate and heparan sulfate. It hydrolyzes the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. It also binds 1 Ca2+ ion per subunit.
+Iduronate 2-sulfatase is located in the lysosome.[1] It is involved in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.[1] I2S hydrolyzes the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.[1] Dermatan sulfate and heparan sulfate are complex glycosaminoglycans, which are essentially large sugar molecules.[2] They play important roles in cell adhesion, growth, proliferation and repair, and their degradation and recycling in the lysosome are essential for cellular maintenance.[2]
 == Relevance ==