PROTAC: Difference between revisions
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==Predicting PROTAC-induced ternary complexes== | ==Predicting PROTAC-induced ternary complexes== | ||
PRosettaC <ref>PRosettaC https://prosettac.weizmann.ac.il, a computational resource for the prediction of PROTAC-induced ternary complexes.</ref> is a computational resource for the prediction of PROTAC-induced ternary complexes <ref>pmid 32976709</ref>. PRosettaC receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex. | PRosettaC <ref>PRosettaC https://prosettac.weizmann.ac.il, a computational resource for the prediction of PROTAC-induced ternary complexes.</ref> is a computational resource for the prediction of PROTAC-induced ternary complexes <ref>pmid 32976709</ref>. PRosettaC receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex. Other methods become available <ref>pmid 32969649</ref><ref>pmid 33625214</ref>. | ||
==PROTACpedia== | ==PROTACpedia== | ||
