PROTAC: Difference between revisions
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<!-- <StructureSection load='' size='340' side='right' caption='' scene='87/876131/Protac/1'> --> | <!-- <StructureSection load='' size='340' side='right' caption='' scene='87/876131/Protac/1'> --> | ||
A Proteolysis-Targeting Chimera (PROTAC) is a small protein with two active domains joined by a linker. PROTACs represent an alternative to conventional enzyme inhibitors, by enabling [[Proteasome|proteasome]] induced degradation of the target protein <ref>pmid 28288108</ref>. | A Proteolysis-Targeting Chimera (PROTAC) is a small protein with two active domains joined by a linker. PROTACs represent an alternative to conventional enzyme inhibitors, by enabling [[Proteasome|proteasome]] induced degradation of the target protein <ref>pmid 28288108</ref>. | ||
{| class="wikitable" | |||
|- | |||
! Target | |||
! PROTAC | |||
! Structure | |||
|- | |||
| BRAF kinase domain | |||
| P4B | |||
| [[6uuo]] | |||
|- | |||
| DDB1-CRBN-BRD4(BD1) | |||
| dBET6 | |||
| [[6boy]] | |||
|} | |||
[[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | [[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]] | ||
