Domain: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) No edit summary |
Eric Martz (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{Stub}} | {{Stub}} | ||
A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but | A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but many proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer. | ||
In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>. | In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>. In 2006, 64% of all protein structures in CATH were single domain chains. 27% were two-domain chains<ref name="cath2006" />. | ||
Examples: | Examples: | ||
