7bbp: Difference between revisions
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==== | ==Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac== | ||
<StructureSection load='7bbp' size='340' side='right'caption='[[7bbp]]' scene=''> | <StructureSection load='7bbp' size='340' side='right'caption='[[7bbp]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7bbp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BBP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bbp OCA], [https://pdbe.org/7bbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bbp RCSB], [https://www.ebi.ac.uk/pdbsum/7bbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bbp ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bbp OCA], [https://pdbe.org/7bbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bbp RCSB], [https://www.ebi.ac.uk/pdbsum/7bbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bbp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | |||
==See Also== | |||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra C]] | |||
[[Category: Brennan PE]] | |||
[[Category: Burgess-Brown NA]] | |||
[[Category: Edwards AM]] | |||
[[Category: Fairhead M]] | |||
[[Category: Krojer T]] | |||
[[Category: Szykowska A]] | |||
[[Category: Talon R]] | |||
[[Category: Von Delft F]] | |||
