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==The Structure of the Cyclin T-binding domain of Hexim1 reveals the molecular basis for regulation of transcription elongation==
==The Structure of the Cyclin T-binding domain of Hexim1 reveals the molecular basis for regulation of transcription elongation==
<StructureSection load='2gd7' size='340' side='right'caption='[[2gd7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2gd7' size='340' side='right'caption='[[2gd7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2gd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GD7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2gd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GD7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hexim1 (255-359), G256A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gd7 OCA], [https://pdbe.org/2gd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2gd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gd7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gd7 OCA], [https://pdbe.org/2gd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2gd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gd7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HEXI1_HUMAN HEXI1_HUMAN] Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.<ref>PMID:12941847</ref> <ref>PMID:12581153</ref> <ref>PMID:14580347</ref> <ref>PMID:12832472</ref> <ref>PMID:15201869</ref> <ref>PMID:15713661</ref> <ref>PMID:15940264</ref> <ref>PMID:15941832</ref> <ref>PMID:17088550</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dames, S A]]
[[Category: Dames SA]]
[[Category: Clp-1]]
[[Category: Coiled coil]]
[[Category: Edg1]]
[[Category: Hexim1]]
[[Category: Maq1]]
[[Category: P-tefb nmr]]
[[Category: Positive transcription elongation factor-b]]
[[Category: Structure determination]]
[[Category: Symmetric dimer]]
[[Category: Transcription]]
[[Category: Transcription elongation]]
[[Category: Transcription regulation]]
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