6lir: Difference between revisions
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==== | ==crystal structure of chicken TCR for 2.0== | ||
<StructureSection load='6lir' size='340' side='right'caption='[[6lir]]' scene=''> | <StructureSection load='6lir' size='340' side='right'caption='[[6lir]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[6lir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LIR FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lir OCA], [https://pdbe.org/6lir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lir RCSB], [https://www.ebi.ac.uk/pdbsum/6lir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lir ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.091Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lir OCA], [https://pdbe.org/6lir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lir RCSB], [https://www.ebi.ac.uk/pdbsum/6lir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lir ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In this work, chicken HPAIV H5N1 epitope-specific TCRalphabeta (ch-TCRalphabeta) was isolated and its structure was determined. The Calpha domain of ch-TCRalphabeta does not exhibit the typical structure of human TCRalphabeta, and the DE loop extends outward, resulting in close proximity between the Calpha domain of ch-TCRalphabeta and CD3epsilondelta/gamma. The FG loop of the Cbeta domain of ch-TCRalphabeta is shorter. The changes in the C domains of ch-TCRalphabeta and the difference in chicken CD3epsilondelta/gamma confirm that the complexes formed by TCRalphabeta and CD3epsilondelta/gamma differ from those in humans. In the chicken complex, a positively charged cleft is formed between the two CDR3 loops that might accommodate the acidic side chains of the chicken pMHC-I-bound HPAIV epitope intermediate portion oriented toward ch-TCRalphabeta. This is the first reported structure of chicken TCRalphabeta, and it provides a structural model of the ancestral TCR system in the immune synapses between T cells and antigen-presenting cells in lower vertebrates. | |||
Structural and Biophysical Insights into the TCRalphabeta Complex in Chickens.,Zhang L, Liu Y, Meng G, Liang R, Zhang B, Xia C iScience. 2020 Nov 20;23(12):101828. doi: 10.1016/j.isci.2020.101828. eCollection , 2020 Dec 18. PMID:33305184<ref>PMID:33305184</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6lir" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Gallus gallus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Xia C]] | ||
[[Category: Zhang L]] | |||
