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==NMR structure of protein Hydrogenase-1 operon protein hyaE from Escherichia coli: Northeast Structural Genomics Consortium Target ER415==
==NMR structure of protein Hydrogenase-1 operon protein hyaE from Escherichia coli: Northeast Structural Genomics Consortium Target ER415==
<StructureSection load='2hfd' size='340' side='right'caption='[[2hfd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2hfd' size='340' side='right'caption='[[2hfd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2hfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hyaE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfd OCA], [https://pdbe.org/2hfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfd RCSB], [https://www.ebi.ac.uk/pdbsum/2hfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfd ProSAT], [https://www.topsan.org/Proteins/NESGC/2hfd TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfd OCA], [https://pdbe.org/2hfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfd RCSB], [https://www.ebi.ac.uk/pdbsum/2hfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfd ProSAT], [https://www.topsan.org/Proteins/NESGC/2hfd TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HYAE_ECOLI HYAE_ECOLI]] Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon.  
[https://www.uniprot.org/uniprot/HYAE_ECOLI HYAE_ECOLI] Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfd ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfd ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the 142-residue protein Q8ZP25_SALTY encoded in the genome of Salmonella typhimurium LT2 was determined independently by NMR and X-ray crystallography, and the structure of the 140-residue protein HYAE_ECOLI encoded in the genome of Escherichia coli was determined by NMR. The two proteins belong to Pfam (Finn et al. 34:D247-D251, 2006) PF07449, which currently comprises 50 members, and belongs itself to the 'thioredoxin-like clan'. However, protein HYAE_ECOLI and the other proteins of Pfam PF07449 do not contain the canonical Cys-X-X-Cys active site sequence motif of thioredoxin. Protein HYAE_ECOLI was previously classified as a [NiFe] hydrogenase-1 specific chaperone interacting with the twin-arginine translocation (Tat) signal peptide. The structures presented here exhibit the expected thioredoxin-like fold and support the view that members of Pfam family PF07449 specifically interact with Tat signal peptides.
Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif.,Parish D, Benach J, Liu G, Singarapu KK, Xiao R, Acton T, Su M, Bansal S, Prestegard JH, Hunt J, Montelione GT, Szyperski T J Struct Funct Genomics. 2008 Dec;9(1-4):41-9. Epub 2008 Nov 26. PMID:19039680<ref>PMID:19039680</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2hfd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Acton, T]]
[[Category: Acton T]]
[[Category: Atreya, H S]]
[[Category: Atreya HS]]
[[Category: Baran, M]]
[[Category: Baran M]]
[[Category: Cunningham, K]]
[[Category: Cunningham K]]
[[Category: Eletsky, A]]
[[Category: Eletsky A]]
[[Category: Janjua, H]]
[[Category: Janjua H]]
[[Category: Liu, G]]
[[Category: Liu G]]
[[Category: Liu, J]]
[[Category: Liu J]]
[[Category: Ma, L C]]
[[Category: Ma LC]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Parish D]]
[[Category: Parish, D]]
[[Category: Rost B]]
[[Category: Rost, B]]
[[Category: Singarapu KK]]
[[Category: Singarapu, K K]]
[[Category: Swapna GVT]]
[[Category: Swapna, G V.T]]
[[Category: Szyperski T]]
[[Category: Szyperski, T]]
[[Category: Xiao R]]
[[Category: Xiao, R]]
[[Category: Xu D]]
[[Category: Xu, D]]
[[Category: Alfa-beta]]
[[Category: Nesgc]]
[[Category: Protein structure]]
[[Category: PSI, Protein structure initiative]]
[[Category: Unknown function]]
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