1dyq: Difference between revisions

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[[Image:1dyq.gif|left|200px]]
{{Seed}}
[[Image:1dyq.png|left|200px]]


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{{STRUCTURE_1dyq|  PDB=1dyq  |  SCENE=  }}  
{{STRUCTURE_1dyq|  PDB=1dyq  |  SCENE=  }}  


'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''
===STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE===




==Overview==
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Staphylococcal enterotoxins (SEs) are superantigenic protein toxins responsible for a number of life-threatening diseases. The X-ray structure of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and Y92A) vaccine reveals a cascade of structural rearrangements located in three loop regions essential for binding the alpha subunit of major histocompatibility complex class II (MHC-II) molecules. A comparison of hypothetical model complexes between SEA and the SEA triple mutant with MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic interactions necessary for forming the complex. Extensive dislocation of the disulfide loop in particular interferes with MHC-IIalpha binding. The triple-mutant structure provides new insights into the loss of superantigenicity and toxicity of an engineered superantigen and provides a basis for further design of enterotoxin vaccines.
The line below this paragraph, {{ABSTRACT_PUBMED_11847286}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11847286}}


==About this Structure==
==About this Structure==
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[[Category: Staphylococcal enterotoxin type some]]
[[Category: Staphylococcal enterotoxin type some]]
[[Category: Vaccine]]
[[Category: Vaccine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:26:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:49:22 2008''

Revision as of 20:49, 30 June 2008

File:1dyq.png

Template:STRUCTURE 1dyq

STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE

Template:ABSTRACT PUBMED 11847286

About this Structure

1DYQ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci. 2002 Mar;11(3):642-51. PMID:11847286

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