7b66: Difference between revisions
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==Structure of NUDT15 R139H Mutant in complex with TH7755== | ==Structure of NUDT15 R139H Mutant in complex with TH7755== | ||
<StructureSection load='7b66' size='340' side='right'caption='[[7b66]]' scene=''> | <StructureSection load='7b66' size='340' side='right'caption='[[7b66]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B66 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7b66]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B66 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b66 OCA], [https://pdbe.org/7b66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b66 RCSB], [https://www.ebi.ac.uk/pdbsum/7b66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b66 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SYW:(R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one'>SYW</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nucleotide_diphosphatase Nucleotide diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.9 3.6.1.9] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b66 OCA], [https://pdbe.org/7b66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b66 RCSB], [https://www.ebi.ac.uk/pdbsum/7b66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b66 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/NUD15_HUMAN NUD15_HUMAN]] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.<ref>PMID:19419956</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rehling D]] | [[Category: Nucleotide diphosphatase]] | ||
[[Category: Stenmark P]] | [[Category: Rehling, D]] | ||
[[Category: Stenmark, P]] | |||
[[Category: Complex]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Nucleoside triphosphate pyrophosphohydrolase]] | |||
Revision as of 10:46, 31 March 2021
Structure of NUDT15 R139H Mutant in complex with TH7755
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