7cn8: Difference between revisions

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<StructureSection load='7cn8' size='340' side='right'caption='[[7cn8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='7cn8' size='340' side='right'caption='[[7cn8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7cn8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pangolin_coronavirus Pangolin coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CN8 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CN8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cn8 OCA], [https://pdbe.org/7cn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cn8 RCSB], [https://www.ebi.ac.uk/pdbsum/7cn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cn8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cn8 OCA], [https://pdbe.org/7cn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cn8 RCSB], [https://www.ebi.ac.uk/pdbsum/7cn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cn8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely related to SARS-CoV-2. All three receptor-binding domains (RBDs) of these two spike trimers are in the "down" conformation, indicating they are more prone to adopt the receptor-binding inactive state. However, we found that the PCoV_GX, but not the RaTG13, spike is comparable to the SARS-CoV-2 spike in binding the human ACE2 receptor and supporting pseudovirus cell entry. We further identified critical residues in the RBD underlying different activities of the RaTG13 and PCoV_GX/SARS-CoV-2 spikes. These results collectively indicate that tight RBD-ACE2 binding and efficient RBD conformational sampling are required for the evolution of SARS-CoV-2 to gain highly efficient infection.
Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution.,Zhang S, Qiao S, Yu J, Zeng J, Shan S, Tian L, Lan J, Zhang L, Wang X Nat Commun. 2021 Mar 11;12(1):1607. doi: 10.1038/s41467-021-21767-3. PMID:33707453<ref>PMID:33707453</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7cn8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pangolin coronavirus]]
[[Category: Qiao S]]
[[Category: Qiao, S]]
[[Category: Tian L]]
[[Category: Tian, L]]
[[Category: Wang X]]
[[Category: Wang, X]]
[[Category: Yu J]]
[[Category: Yu, J]]
[[Category: Zeng J]]
[[Category: Zeng, J]]
[[Category: Zhang S]]
[[Category: Zhang, S]]
[[Category: Spike]]
[[Category: Viral protein]]
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