1e09: Difference between revisions

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[[Image:1e09.gif|left|200px]]
{{Seed}}
[[Image:1e09.png|left|200px]]


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{{STRUCTURE_1e09|  PDB=1e09  |  SCENE=  }}  
{{STRUCTURE_1e09|  PDB=1e09  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE MAJOR CHERRY ALLERGEN PRU AV 1'''
===SOLUTION STRUCTURE OF THE MAJOR CHERRY ALLERGEN PRU AV 1===




==Overview==
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Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To provide a basis for examining the cross-reactivity on a structural level, we used heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen allergen, we propose an explanation for a significant aspect of the observed cross-reactivity pattern among the family of allergens under consideration. The large hydrophobic cavity expected to be important for the still unknown physiological function of Bet v 1 is conserved in Pru av 1. Structural homology to a domain of human MLN64 associated with cholesterol transport suggests phytosteroids as putative ligands for Pru av 1. NMR spectroscopy provides experimental evidence that Pru av 1 interacts with phytosteroids, and molecular modeling shows that the hydrophobic cavity is large enough to accommodate two such molecules.
The line below this paragraph, {{ABSTRACT_PUBMED_11287426}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11287426 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11287426}}


==About this Structure==
==About this Structure==
1E09 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Prunus_avium Prunus avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA].  
1E09 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Prunus_avium Prunus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA].  


==Reference==
==Reference==
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[[Category: Pathogenesis-related protein]]
[[Category: Pathogenesis-related protein]]
[[Category: Structure]]
[[Category: Structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:29:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:55:23 2008''

Revision as of 20:55, 30 June 2008

File:1e09.png

Template:STRUCTURE 1e09

SOLUTION STRUCTURE OF THE MAJOR CHERRY ALLERGEN PRU AV 1

Template:ABSTRACT PUBMED 11287426

About this Structure

1E09 is a Single protein structure of sequence from Prunus avium. Full experimental information is available from OCA.

Reference

Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1., Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P, J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426

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