7lj9: Difference between revisions
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==Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate== | ==Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate== | ||
<StructureSection load='7lj9' size='340' side='right'caption='[[7lj9]]' scene=''> | <StructureSection load='7lj9' size='340' side='right'caption='[[7lj9]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJ9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lj9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJ9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj9 OCA], [https://pdbe.org/7lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj9 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6ui9|6ui9]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACLY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj9 OCA], [https://pdbe.org/7lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
An amendment to this paper has been published and can be accessed via a link at the top of the paper. | |||
Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase.,Wei X, Schultz K, Bazilevsky GA, Vogt A, Marmorstein R Nat Struct Mol Biol. 2020 May;27(5):511-513. doi: 10.1038/s41594-020-0421-9. PMID:32242119<ref>PMID:32242119</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7lj9" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: ATP citrate synthase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Marmorstein R]] | [[Category: Marmorstein, R]] | ||
[[Category: Wei X]] | [[Category: Wei, X]] | ||
[[Category: Lyase]] | |||
