1e3g: Difference between revisions

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[[Image:1e3g.~~gif~~|left|200px]]

[[Image:1e3g.png|left|200px]]

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~~'''~~HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)~~'''~~

===HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)===

~~==Overview==~~

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The ~~crystal structures of~~ the ~~human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with~~ the ~~same ligand metribolone~~ (~~R1881) have been determined~~. ~~Both three-dimensional structures show the typical nuclear receptor fold~~. ~~The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR~~ is ~~most likely the source for the specificity of R1881 to~~ the ~~hAR~~. ~~The structural implications of the 14 known mutations in the ligand~~-~~binding pocket of the hAR ligand~~-binding domains associated with either prostate cancer or the partial or complete androgen receptor insensitivity syndrome were analyzed. The effects of most of these mutants could be explained on the basis of the crystal structure.

The line below this paragraph, {{ABSTRACT_PUBMED_10840043}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10840043 is the PubMed ID number.

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==About this Structure==

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[[Category: Human androgen receptor]]

[[Category: Ligand binding domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 14~~:36:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:05:14 2008''

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-[[Image:1e3g.gif|left|200px]]
+{{Seed}}
+[[Image:1e3g.png|left|200px]]
 <!--
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 {{STRUCTURE_1e3g|  PDB=1e3g  |  SCENE=  }}
-'''HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)'''
+===HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)===
-==Overview==
+<!--
-The crystal structures of the human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with the same ligand metribolone (R1881) have been determined. Both three-dimensional structures show the typical nuclear receptor fold. The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR is most likely the source for the specificity of R1881 to the hAR. The structural implications of the 14 known mutations in the ligand-binding pocket of the hAR ligand-binding domains associated with either prostate cancer or the partial or complete androgen receptor insensitivity syndrome were analyzed. The effects of most of these mutants could be explained on the basis of the crystal structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_10840043}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10840043 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10840043}}
 ==About this Structure==
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 [[Category: Human androgen receptor]]
 [[Category: Ligand binding domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:36:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:05:14 2008''