7d2v: Difference between revisions
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<StructureSection load='7d2v' size='340' side='right'caption='[[7d2v]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='7d2v' size='340' side='right'caption='[[7d2v]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7d2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[7d2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D2V FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66F:N-{3-[(5R)-3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>66F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66F:N-{3-[(5R)-3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>66F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2v OCA], [https://pdbe.org/7d2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2v RCSB], [https://www.ebi.ac.uk/pdbsum/7d2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2v OCA], [https://pdbe.org/7d2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2v RCSB], [https://www.ebi.ac.uk/pdbsum/7d2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7d2v" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7d2v" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Beta secretase 3D structures|Beta secretase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ando S]] | |||
[[Category: Ando | [[Category: Asada N]] | ||
[[Category: Asada | [[Category: Fuchino K]] | ||
[[Category: Fuchino | [[Category: Fujimoto K]] | ||
[[Category: Fujimoto | [[Category: Gijsen HJM]] | ||
[[Category: Gijsen | [[Category: Ito H]] | ||
[[Category: Ito | [[Category: Kanegawa N]] | ||
[[Category: Kanegawa | [[Category: Kusakabe KI]] | ||
[[Category: Kusakabe | [[Category: Matsuoka E]] | ||
[[Category: Matsuoka | [[Category: Moechars D]] | ||
[[Category: Moechars | [[Category: Rombouts FJR]] | ||
[[Category: Rombouts | [[Category: Suzuki S]] | ||
[[Category: Suzuki | [[Category: Tadano G]] | ||
[[Category: Tadano | [[Category: Tonomura Y]] | ||
[[Category: Tonomura | [[Category: Yamamoto S]] | ||
[[Category: Yamamoto | [[Category: Yamamoto T]] | ||
[[Category: Yamamoto | [[Category: Yoshida S]] | ||
[[Category: Yoshida | |||
