1a6a: Difference between revisions

Line 1:

[[Image:1a6a.gif|left|200px]]<br />

[[Image:1a6a.gif|left|200px]]<br /><applet load="1a6a" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1a6a" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1a6a, resolution 2.75Å" />

'''THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3'''<br />

==Overview==

A complex between HLA-DR3 and a fragment of invariant chain called CLIP, was isolated from a human cell line defective in antigen presentation and, its X-ray crystal structure determined. Previous data indicate that this, complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes., The structure shows that the CLIP fragment binds to DR3 in a way almost, identical to that in which antigenic peptides bind class II, histocompatibility glycoproteins. The structure is the substrate for the, loading of antigenic peptides by an exchange process catalysed by DM.

A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.

==About this Structure==

1A6A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1A6A OCA].

1A6A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6A OCA].

==Reference==

Line 17:

Line 16:

[[Category: Ghosh, P.]]

[[Category: Mellins, E.]]

[[Category: Wiley, D.C.]]

[[Category: Wiley, D C.]]

[[Category: NAG]]

[[Category: complex (transmembrane/glycoprotein)]]

[[Category: mhc glycoprotein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 15~~:56:~~09 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:25 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1a6a.gif|left|200px]]<br />
+[[Image:1a6a.gif|left|200px]]<br /><applet load="1a6a" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1a6a" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1a6a, resolution 2.75&Aring;" />
 '''THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3'''<br />
 ==Overview==
-A complex between HLA-DR3 and a fragment of invariant chain called CLIP, was isolated from a human cell line defective in antigen presentation and, its X-ray crystal structure determined. Previous data indicate that this, complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes., The structure shows that the CLIP fragment binds to DR3 in a way almost, identical to that in which antigenic peptides bind class II, histocompatibility glycoproteins. The structure is the substrate for the, loading of antigenic peptides by an exchange process catalysed by DM.
+A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.
 ==About this Structure==
-A6A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A6A OCA].
+A6A is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6A OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Ghosh, P.]]
 [[Category: Mellins, E.]]
-[[Category: Wiley, D.C.]]
+[[Category: Wiley, D C.]]
 [[Category: NAG]]
 [[Category: complex (transmembrane/glycoprotein)]]
 [[Category: mhc glycoprotein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 15:56:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:25 2008''