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==Second BRCT domain of NBS1==
==Second BRCT domain of NBS1==
<StructureSection load='2k2w' size='340' side='right'caption='[[2k2w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2k2w' size='340' side='right'caption='[[2k2w]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2W FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2W FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NBS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2w OCA], [https://pdbe.org/2k2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2w RCSB], [https://www.ebi.ac.uk/pdbsum/2k2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2w OCA], [https://pdbe.org/2k2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2w RCSB], [https://www.ebi.ac.uk/pdbsum/2k2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/Q6EKW1_XENLA Q6EKW1_XENLA]] Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis (By similarity).[PIRNR:PIRNR011869]  
[https://www.uniprot.org/uniprot/Q6XV80_XENLA Q6XV80_XENLA]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Botuyan, M]]
[[Category: Botuyan M]]
[[Category: Cui, G]]
[[Category: Cui G]]
[[Category: Mer, G]]
[[Category: Mer G]]
[[Category: Xu, C]]
[[Category: Xu C]]
[[Category: Brct domain]]
[[Category: Cell cycle]]
[[Category: Cell cycle checkpoint]]
[[Category: Dna repair]]
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