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==Chemical shift structure of COLICIN E9 DNASE domain with its cognate immunity protein IM9==
==Chemical shift structure of COLICIN E9 DNASE domain with its cognate immunity protein IM9==
<StructureSection load='2k5x' size='340' side='right'caption='[[2k5x]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2k5x' size='340' side='right'caption='[[2k5x]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5X FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1imq|1imq]], [[1fsj|1fsj]], [[1emv|1emv]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">imm, ceiE9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), col, cei ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5x OCA], [https://pdbe.org/2k5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5x RCSB], [https://www.ebi.ac.uk/pdbsum/2k5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5x OCA], [https://pdbe.org/2k5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5x RCSB], [https://www.ebi.ac.uk/pdbsum/2k5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. [[https://www.uniprot.org/uniprot/CEA9_ECOLX CEA9_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity.  Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.  
[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cavalli, A]]
[[Category: Cavalli A]]
[[Category: Montalvao, R W]]
[[Category: Montalvao RW]]
[[Category: Vendruscolo, M]]
[[Category: Vendruscolo M]]
[[Category: Antibiotic]]
[[Category: Antimicrobial]]
[[Category: Bacteriocin]]
[[Category: Bacteriocin immunity]]
[[Category: Colicin e9]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Immune system-hydrolase complex]]
[[Category: Immunity protein im9]]
[[Category: Metal-binding]]
[[Category: Nuclease]]
[[Category: Plasmid]]
[[Category: Zinc]]
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