1a7x: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="1a7x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7x, resolution 2.0Å" /> '''FKBP12-FK1012 COMPLE... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1a7x.gif|left|200px]]<br /> | [[Image:1a7x.gif|left|200px]]<br /><applet load="1a7x" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1a7x" size=" | |||
caption="1a7x, resolution 2.0Å" /> | caption="1a7x, resolution 2.0Å" /> | ||
'''FKBP12-FK1012 COMPLEX'''<br /> | '''FKBP12-FK1012 COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
A ligand that simultaneously binds two proteins must have two high | A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design. | ||
==About this Structure== | ==About this Structure== | ||
1A7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FKA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http:// | 1A7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FKA:'>FKA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7X OCA]. | ||
==Reference== | ==Reference== | ||
| Line 16: | Line 15: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clardy, J.]] | [[Category: Clardy, J.]] | ||
[[Category: Schultz, L | [[Category: Schultz, L W.]] | ||
[[Category: FKA]] | [[Category: FKA]] | ||
[[Category: immunophilin]] | [[Category: immunophilin]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:50 2008'' | ||
