1j5i: Difference between revisions
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==Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore== | ==Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore== | ||
<StructureSection load='1j5i' size='340' side='right'caption='[[1j5i | <StructureSection load='1j5i' size='340' side='right'caption='[[1j5i]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J5I FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [https://pdbe.org/1j5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [https://www.ebi.ac.uk/pdbsum/1j5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5i ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [https://pdbe.org/1j5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [https://www.ebi.ac.uk/pdbsum/1j5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Streptomyces carzinostaticus]] | [[Category: Streptomyces carzinostaticus]] | ||
[[Category: Caddick S]] | |||
[[Category: Caddick | [[Category: Finucane MD]] | ||
[[Category: Finucane | [[Category: Muskett FW]] | ||
[[Category: Muskett | [[Category: Urbaniak MD]] | ||
[[Category: Urbaniak | [[Category: Woolfson DN]] | ||
[[Category: Woolfson | |||
Revision as of 18:42, 29 November 2023
Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
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