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==UNMYRISTOYLATED GCAP-2 WITH THREE CALCIUM IONS BOUND==
==UNMYRISTOYLATED GCAP-2 WITH THREE CALCIUM IONS BOUND==
<StructureSection load='1jba' size='340' side='right'caption='[[1jba]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
<StructureSection load='1jba' size='340' side='right'caption='[[1jba]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBA FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jba OCA], [https://pdbe.org/1jba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jba RCSB], [https://www.ebi.ac.uk/pdbsum/1jba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jba ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jba OCA], [https://pdbe.org/1jba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jba RCSB], [https://www.ebi.ac.uk/pdbsum/1jba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jba ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GUC1B_BOVIN GUC1B_BOVIN]] Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.  
[https://www.uniprot.org/uniprot/GUC1B_BOVIN GUC1B_BOVIN] Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Guanylate cyclase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ames, J B]]
[[Category: Ames JB]]
[[Category: Dizhoor, A M]]
[[Category: Dizhoor AM]]
[[Category: Ikura, M]]
[[Category: Ikura M]]
[[Category: Palczewski, K]]
[[Category: Palczewski K]]
[[Category: Stryer, L]]
[[Category: Stryer L]]
[[Category: Calcium-binding protein]]
[[Category: Ef-hand]]
[[Category: Guanylyl cyclase regulation]]
[[Category: Lyase]]
Retrieved from "https://proteopedia.org/1jba"