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==Solution Structure of the Ubiquitin-Binding Motif of Human Polymerase Iota==
==Solution Structure of the Ubiquitin-Binding Motif of Human Polymerase Iota==
<StructureSection load='2khu' size='340' side='right'caption='[[2khu]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='2khu' size='340' side='right'caption='[[2khu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2khu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2khu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2khw|2khw]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spg, POLI, RAD30B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khu OCA], [https://pdbe.org/2khu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khu RCSB], [https://www.ebi.ac.uk/pdbsum/2khu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khu OCA], [https://pdbe.org/2khu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khu RCSB], [https://www.ebi.ac.uk/pdbsum/2khu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG] [https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2khu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2khu" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strsg]]
[[Category: Streptococcus sp. 'group G']]
[[Category: Bienko, M]]
[[Category: Bienko M]]
[[Category: Bomar, M G]]
[[Category: Bomar MG]]
[[Category: Dikic, I]]
[[Category: D'Souza S]]
[[Category: Souza, S D]]
[[Category: Dikic I]]
[[Category: Walker, G]]
[[Category: Walker G]]
[[Category: Immunoglobulin g-binding protein]]
[[Category: Polymerase iota]]
[[Category: Tl]]
[[Category: Transferase-protein binding complex]]
[[Category: Translesion synthesis]]
[[Category: Ubiquitin-binding domain]]
[[Category: Ubiquitin-binding protein]]
[[Category: Ubm]]
Retrieved from "https://proteopedia.org/2khu"