Sandbox Reserved 1670: Difference between revisions
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== Other important features == | == Other important features == | ||
The aromatic box consists of Trp160, Tyr163, Trp450, Phe456, and Tyr468. The amino acids provide a hydrophobic pocket for binding the octanal ligand. These residues provide pi stacking to stabilize the structure . Mutations to these residues affected the efficiency of the octanal but it wasn't too significant, meaning the protein was still able to function with the mutations, its binding ability was not effected. | The aromatic box consists of Trp160, Tyr163, Trp450, Phe456, and Tyr468. The amino acids provide a hydrophobic pocket that is needed for binding the octanal ligand becasue it requires a hydrophobic environment. These residues provide pi stacking to stabilize the structure . Mutations to these residues affected the efficiency of the octanal but it wasn't too significant, meaning the protein was still able to function with the mutations, its binding ability was not effected. | ||
<scene name='87/873232/Aromatic_box_around_octanal/1'>Aromatic box around octanal</scene> | <scene name='87/873232/Aromatic_box_around_octanal/1'>Aromatic box around octanal</scene> | ||
The nicotinamide ring is held by Van Der Waals interactions using the residues Leu258, Leu419, and Phe456 and is also hydrogen bonded by Leu258. The nicotinamide helps stabilize the NAD+ through these interactions,and a hydrogen bond to water. | |||
</StructureSection> | </StructureSection> | ||
