Sandbox Reserved 1674: Difference between revisions
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This protein has eight chains. Each <scene name='87/873236/Secondary_structure/1'>chain</scene> has eleven separate alpha helixes, and nine separate beta sheets. Some of the chains do bind to a GOL to help with stability. Within each chain, there are two of the catalytic amino acids within helix three. The last catalytic amino acid is located in helix seven. Both of those helices form important interactions with the ligands because of those catalytic amino acids. | This protein has eight chains. Each <scene name='87/873236/Secondary_structure/1'>chain</scene> has eleven separate alpha helixes, and nine separate beta sheets. Some of the chains do bind to a GOL to help with stability. Within each chain, there are two of the catalytic amino acids within helix three. The last catalytic amino acid is located in helix seven. Both of those helices form important interactions with the ligands because of those catalytic amino acids. | ||
The important<scene name='87/873236/Amino_acid_tert/1'> tertiary structure</scene> is how the protein folds to allow the amino acids in the catalytic triad to be near each other because in the sequence, the amino acids are not near each other. By folding, the protein is able to create the binding pocket that holds the catalytic amino acids that help Beta- Lactamase function normally. | The important<scene name='87/873236/Amino_acid_tert/1'> tertiary structure</scene> is how the protein folds to allow the amino acids in the catalytic triad to be near each other because in the sequence, the amino acids are not near each other. By folding, the protein is able to create the binding pocket that holds the catalytic amino acids that help Beta- Lactamase function normally. | ||
In the <scene name='87/873236/Space_fill/ | In the<scene name='87/873236/Space_fill/2'> space fill</scene> view of the enzyme, you can see the small binding pocket that is created to hold the substrate better. | ||
== Other important features == | == Other important features == | ||
As previously mentioned, this enzyme does also utilize a <scene name='87/873236/Lysine_73/2'>lysine</scene> at residue 73. This is to help shuttle protons through the reaction. S170 uses it in the first part of the reaction and Glu166 is activated by this as well, and completes the reaction, as well as recreates the S170, by donating more protons. This can allow the enzyme to work multiple times and retain it's function overtime which is not good in regards to drug resistance. | As previously mentioned, this enzyme does also utilize a <scene name='87/873236/Lysine_73/2'>lysine</scene> at residue 73. This is to help shuttle protons through the reaction. S170 uses it in the first part of the reaction and Glu166 is activated by this as well, and completes the reaction, as well as recreates the S170, by donating more protons. This can allow the enzyme to work multiple times and retain it's function overtime which is not good in regards to drug resistance. | ||
