1ad6: Difference between revisions

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[[Image:1ad6.gif|left|200px]]<br />

[[Image:1ad6.gif|left|200px]]<br /><applet load="1ad6" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ad6" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ad6, resolution 2.3Å" />

'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''<br />

==Overview==

The pocket region of retinoblastoma tumour suppressor (Rb) is essential, for tumour suppressing activity. The Rb pocket is primarily composed of, two domains, A and B. We have determined the X-ray crystal structure of, domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine, alpha-helices. The overall arrangement of helices in domain A is, remarkably similar to the cyclin-box folds found in the crystal structures, of cyclin A and TFIIB. This structure, along with domain B which is, predicted to be homologous to the cyclin-box, suggests that the Rb pocket, is composed of two cyclin-box fold domains. We present the, structural/functional features of the Rb pocket, and the potential binding, region for cellular or viral proteins within domain A.

The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.

==Disease==

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==About this Structure==

1AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].

1AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Cho, Y.]]

[[Category: Kim, H.Y.]]

[[Category: Kim, H Y.]]

[[Category: dna-binding]]

[[Category: transcription regulation]]

[[Category: tumor suppressor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 15~~:57:~~42 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:23 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ad6.gif|left|200px]]<br />
+[[Image:1ad6.gif|left|200px]]<br /><applet load="1ad6" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ad6" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ad6, resolution 2.3&Aring;" />
 '''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''<br />
 ==Overview==
-The pocket region of retinoblastoma tumour suppressor (Rb) is essential, for tumour suppressing activity. The Rb pocket is primarily composed of, two domains, A and B. We have determined the X-ray crystal structure of, domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine, alpha-helices. The overall arrangement of helices in domain A is, remarkably similar to the cyclin-box folds found in the crystal structures, of cyclin A and TFIIB. This structure, along with domain B which is, predicted to be homologous to the cyclin-box, suggests that the Rb pocket, is composed of two cyclin-box fold domains. We present the, structural/functional features of the Rb pocket, and the potential binding, region for cellular or viral proteins within domain A.
+The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].
+AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Cho, Y.]]
-[[Category: Kim, H.Y.]]
+[[Category: Kim, H Y.]]
 [[Category: dna-binding]]
 [[Category: transcription regulation]]
 [[Category: tumor suppressor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 15:57:42 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:23 2008''