1nqc: Difference between revisions

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<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1npz|1npz]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [https://pdbe.org/1nqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [https://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [https://pdbe.org/1nqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [https://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.  
[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cathepsin S]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ammirati, M]]
[[Category: Ammirati M]]
[[Category: Cygler, M]]
[[Category: Cygler M]]
[[Category: Danley, D E]]
[[Category: Danley DE]]
[[Category: Griffor, M C]]
[[Category: Griffor MC]]
[[Category: Kamath, A V]]
[[Category: Kamath AV]]
[[Category: Laird, E R]]
[[Category: Laird ER]]
[[Category: Menard, R]]
[[Category: Menard R]]
[[Category: Pauly, T A]]
[[Category: Pauly TA]]
[[Category: Rath, V L]]
[[Category: Rath VL]]
[[Category: Sivaraman, J]]
[[Category: Sivaraman J]]
[[Category: Sulea, T]]
[[Category: Sulea T]]
[[Category: Wang, I K]]
[[Category: Wang IK]]
[[Category: Antigen presentation]]
[[Category: Binding specificity]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]
[[Category: Inhibitor complex]]
[[Category: Structural plasticity]]
[[Category: Structure-based design]]
Retrieved from "https://proteopedia.org/1nqc"