Sandbox GGC16: Difference between revisions
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==Binding Domain== | |||
<scene name='87/874948/Earbindingresiduesbest/1'>Residues at Binding Domain</scene> | <scene name='87/874948/Earbindingresiduesbest/1'>Residues at Binding Domain</scene> | ||
Ets binding domain is conserved across the Ets family of proteins which consist of about 35 proteins with similar functions. | Ets binding domain is conserved across the Ets family of proteins which consist of about 35 proteins with similar functions. | ||
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PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site. | PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site. | ||
== PEST domain == | === PEST domain === | ||
<scene name='87/874948/Pest/2'>PEST domain</scene> | <scene name='87/874948/Pest/2'>PEST domain</scene> | ||
The PEST domain is adjacent to the binding domain and has been found mutated in leukemia patients. It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is hypothesized that the PEST region is a tag for fast degradation of the protein. | The PEST domain is adjacent to the binding domain and has been found mutated in leukemia patients. It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is hypothesized that the PEST region is a tag for fast degradation of the protein. | ||
