Sandbox GGC16: Difference between revisions

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== Name and Location ==
== Function ==
The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence.
Within the nucleus, PU.1 activates transcription of lymphoid genes by binding DNA during hematopoiesis.<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence.
<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene>
 
The protein resides in the nucleus.  
=== Activation ===
A post-translational modification of PU.1 occurs at a serine residue (residue 41). This phosphorylation by protein kinase B (AKT) induces PU.1  activation.<ref>Rieske, P., &amp; Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200</ref>




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