YKL 40: Difference between revisions

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YKL-40 is a non-enzymatic chitinase-like protein. It is able to bind chitin but does not possess the enzymatic activity needed to cleave chitinase. YKL-40 is the human form of chitinase-3 -like protein 1 also referred to as CHI3L1. It is referred to as YKL because of the three amino acid residues (Y, K, and L) present at the N terminus. The 40 comes from the weight of the protein which is around 40kDa. Previous crystallizations have shown a YKL-40 three-dimensional structure that consists of a (β/α)8- barrel domain (***scene). It also has a secondary domain comprised of six antiparallel β-strands with one α-helix (α + β) domain after β7 (***scene). Full-length genomic chains can be observed in UniProt. The complete structure and 3D analysis can be found in the OCA atlas. A summary of statistical data can be found here. For a complete guided tour, FirstGlance is recommended.

<scene name='45/459222/Cv/6'>Chitin tetramer binding site</scene> (water molecules are shown as red spheres; [[1hjv]]).<ref>PMID:12775711</ref>

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Revision as of 17:53, 27 April 2021 view source Safa Ahmed (talk \| contribs) 11 edits No edit summary ← Older edit		Revision as of 18:02, 27 April 2021 view source Safa Ahmed (talk \| contribs) 11 edits No edit summary Newer edit →
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	YKL-40 is a non-enzymatic chitinase-like protein. It is able to bind chitin but does not possess the enzymatic activity needed to cleave chitinase. YKL-40 is the human form of chitinase-3 -like protein 1 also referred to as CHI3L1. It is referred to as YKL because of the three amino acid residues (Y, K, and L) present at the N terminus. The 40 comes from the weight of the protein which is around 40kDa. Previous crystallizations have shown a YKL-40 three-dimensional structure that consists of a (β/α)8- barrel domain (*scene). It also has a secondary domain comprised of six antiparallel β-strands with one α-helix (α + β) domain after β7 (*scene). Full-length genomic chains can be observed in UniProt. The complete structure and 3D analysis can be found in the OCA atlas. A summary of statistical data can be found here. For a complete guided tour, FirstGlance is recommended.		YKL-40 is a non-enzymatic chitinase-like protein. It is able to bind chitin but does not possess the enzymatic activity needed to cleave chitinase. YKL-40 is the human form of chitinase-3 -like protein 1 also referred to as CHI3L1. It is referred to as YKL because of the three amino acid residues (Y, K, and L) present at the N terminus. The 40 comes from the weight of the protein which is around 40kDa. Previous crystallizations have shown a YKL-40 three-dimensional structure that consists of a (β/α)8- barrel domain (*scene). It also has a secondary domain comprised of six antiparallel β-strands with one α-helix (α + β) domain after β7 (*scene). Full-length genomic chains can be observed in UniProt. The complete structure and 3D analysis can be found in the OCA atlas. A summary of statistical data can be found here. For a complete guided tour, FirstGlance is recommended.

	<scene name='45/459222/Cv/6'>Chitin tetramer binding site</scene> (water molecules are shown as red spheres; [[1hjv]]).<ref>PMID:12775711</ref>		<scene name='45/459222/Cv/6'>Chitin tetramer binding site</scene> (water molecules are shown as red spheres; [[1hjv]]).<ref>PMID:12775711</ref>