Sandbox GGC15: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==DNA TOPOISOMERASE I== | ==DNA TOPOISOMERASE I== | ||
<StructureSection load='1A36' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1A36' size='340' side='right' caption='Caption for this structure' scene=''> | ||
Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref>DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref>PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref | Eukaryotic DNA topoisomerase I (topo I) is a protein that reduces the strain from the supercoils that are caused during transcription and translation<ref>DOI 10.1073/pnas.242259599</ref>. There are two types of topoisomerases. Type 1 topoisomerases are monomeric and break one strand of DNA<ref>PMID:9488644</ref>. Type 2 topoisomerases are dimeric, meaning that they made up of two units and break both strands of the DNA helix<ref name="Staker et al., 2002">PMID:9488644</ref>. They are able to pass another part of the duplex through the cut, and close the cut using ATP<ref name="Staker et al., 2002" />. | ||
== Function == | == Function == | ||
Revision as of 20:24, 27 April 2021
DNA TOPOISOMERASE I
| ||||||||||||
