Sandbox GGC4: Difference between revisions
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== Function == | == Function == | ||
HIV-1 Aspartyl Proteases are homo-dimeric proteolytic enzymes, also known as endopeptidases that allow water molecules to act as nucleophiles during catalysis when activated by 2 aspartic acid residues that make up the active site of the protease. Usually, the active site consists of a triad (ASP-THR-GLY) on each monomer with the catalytic residue being D25. | |||
Aspartyl Protease cleaves the Gag and Gag-Pol polyproteins that encode for other structural proteins and enzymes crucial for viral maturation. Hence, HIV-1 Protease Inhibitors have been developed to inhibit the viral protease enzyme to prevent the production and release of mature, infectious HIV virions. Here is how an inhibitor binds to the protease to form a protease-inhibitor complex | |||
== Disease == | == Disease == | ||
