Sandbox GGC15: Difference between revisions

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== Structure ==

'''Human topo 1 is composed of 765 amino acids <ref name="Redinbo" />. The enzyme consist of 4 regions which are the NH2-terminal, core, linker, and COOH-terminal domains<ref name="Redinbo" />. The NH2-terminal is approximately 210 residues long, it is highly charged, disordered, and contains few hydrophobic amino acids<ref name="Redinbo" />. The COOH-terminal domain is made up of residues 713 to 765 and contains the important amino aside Tyrosine ~~223~~<ref name="Redinbo"/>. The location of the active site is at this amino acid<ref name="Redinbo" />. Residues 636 to 712 form the linker domain and they contribute to the enzyme catalytic activity but are not required<ref name="Redinbo" />. The core and the COOH-terminal domain are very important for the catalytic activity<ref name="Redinbo" />.'''

'''Human topo 1 is composed of 765 amino acids <ref name="Redinbo" />. The enzyme consist of 4 regions which are the NH2-terminal, core, linker, and COOH-terminal domains<ref name="Redinbo" />. The NH2-terminal is approximately 210 residues long, it is highly charged, disordered, and contains few hydrophobic amino acids<ref name="Redinbo" />. The <scene name='78/781215/04_27_structure_cooh/1'>COOH-terminal</scene> domain is made up of residues 713 to 765 and contains the important amino aside Tyrosine 723<ref name="Redinbo"/>. The location of the active site is at this amino acid<ref name="Redinbo" />. Residues 636 to 712[Turquoise Color] form the linker domain and they contribute to the enzyme catalytic activity but are not required<ref name="Redinbo" />. The core and the COOH-terminal domain are very important for the catalytic activity<ref name="Redinbo" />.'''

== Active Site ==

Sandbox GGC15: Difference between revisions

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 == Structure ==
-'''Human topo 1 is composed of 765 amino acids <ref name="Redinbo" />. The enzyme consist of 4 regions which are the NH2-terminal, core, linker, and COOH-terminal domains<ref name="Redinbo" />. The NH2-terminal  is approximately 210 residues long, it is highly charged, disordered, and contains few hydrophobic amino acids<ref name="Redinbo" />. The COOH-terminal domain is made up of residues 713 to 765 and contains the important amino aside Tyrosine 223<ref name="Redinbo"/>. The location of the active site is at this amino acid<ref name="Redinbo" />. Residues 636 to 712 form the linker domain and they contribute to the enzyme catalytic activity but are not required<ref name="Redinbo" />. The core and the COOH-terminal domain are very important for the catalytic activity<ref name="Redinbo" />.'''
+'''Human topo 1 is composed of 765 amino acids <ref name="Redinbo" />. The enzyme consist of 4 regions which are the NH2-terminal, core, linker, and COOH-terminal domains<ref name="Redinbo" />. The NH2-terminal  is approximately 210 residues long, it is highly charged, disordered, and contains few hydrophobic amino acids<ref name="Redinbo" />. The <scene name='78/781215/04_27_structure_cooh/1'>COOH-terminal</scene> domain is made up of residues 713 to 765 and contains the important amino aside Tyrosine 723<ref name="Redinbo"/>. The location of the active site is at this amino acid<ref name="Redinbo" />. Residues 636 to 712[Turquoise Color] form the linker domain and they contribute to the enzyme catalytic activity but are not required<ref name="Redinbo" />. The core and the COOH-terminal domain are very important for the catalytic activity<ref name="Redinbo" />.'''
 == Active Site ==