Sandbox GGC9: Difference between revisions
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<scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | <scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | ||
In addition to the catalytic function of aspartic acid residues at 600 and 708, researchers have discovered a trio of residues that are necessary for the DNA cleavage during V(D)J recombination. This trio includes the two catalytic residues as well as a Glutamic acid residue at position 962. | In addition to the catalytic function of aspartic acid residues at 600 and 708, researchers have discovered a trio of residues that are necessary for the DNA cleavage during V(D)J recombination. This trio includes the two catalytic residues as well as a Glutamic acid residue at position 962.[8] | ||
<scene name='75/752271/Dde_motif/1'>Residues responsible for DNA cleavage</scene> | <scene name='75/752271/Dde_motif/1'>Residues responsible for DNA cleavage</scene> | ||
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[7] Fugmann, S., Villey, I., Ptaszek, L., & Schatz, D. (2000). Identification of Two Catalytic Residues in RAG1 that Define a Single Active Site within the RAG1/RAG2 Protein Complex. Molecular Cell, 5(1), 97-107. https://doi.org/10.1016/s1097-2765(00)80406-2 | [7] Fugmann, S., Villey, I., Ptaszek, L., & Schatz, D. (2000). Identification of Two Catalytic Residues in RAG1 that Define a Single Active Site within the RAG1/RAG2 Protein Complex. Molecular Cell, 5(1), 97-107. https://doi.org/10.1016/s1097-2765(00)80406-2 | ||
[8] Swanson P. C. (2001). The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination. Molecular and cellular biology, 21(2), 449–458. https://doi.org/10.1128/MCB.21.2.449-458.2001 | |||
