Sandbox GGC9: Difference between revisions
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The subunit structure is defined as a homodimer. | The subunit structure is defined as a homodimer. | ||
The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure.[5] | The zinc site plays an important role in DNA cleavage; without the zinc site the DNA would not be able to be cleaved and would not form the essential hairpin structure.[5]<scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | ||
<scene name='75/752271/Zinc_ligands/1'>Zinc Ligands</scene> | |||
Initial studies identified aspartic acid residues at positions 600 and 708 function to initiate catalysis.[7] | Initial studies identified aspartic acid residues at positions 600 and 708 function to initiate catalysis.[7]<scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | ||
<scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | |||
In addition to the catalytic function of aspartic acid residues at 600 and 708, researchers have discovered a trio of residues that are necessary for the DNA cleavage during V(D)J recombination. This trio includes the two catalytic residues as well as a Glutamic acid residue at position 962.[8]<scene name='75/752271/Dde_motif/1'>Residues responsible for DNA cleavage</scene> | |||
Residues 265-383 on RAG 1 contain ubiquitin ligase activity. <scene name='75/752271/Ubiquitin_ligase_activity/1'>Ubiquitin activity</scene> | |||
</StructureSection> | </StructureSection> | ||
