1xw4: Difference between revisions

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<StructureSection load='1xw4' size='340' side='right'caption='[[1xw4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1xw4' size='340' side='right'caption='[[1xw4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XW4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XW4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xw3|1xw3]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw4 OCA], [https://pdbe.org/1xw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xw4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xw4 OCA], [https://pdbe.org/1xw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xw4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xw4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN]] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Johnson, L C]]
[[Category: Johnson LC]]
[[Category: Jonsson, T J]]
[[Category: Jonsson TJ]]
[[Category: Lowther, W T]]
[[Category: Lowther WT]]
[[Category: Murray, M S]]
[[Category: Murray MS]]
[[Category: Poole, L B]]
[[Category: Poole LB]]
[[Category: Cysteine]]
[[Category: Oxidoreductase]]
[[Category: Peroxiredoxin]]
[[Category: Sulfinic acid]]
[[Category: Sulfiredoxin]]
[[Category: Sulphiredoxin]]
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