Inositol polyphosphate 5-phosphatase OCRL: Difference between revisions
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At a region towards the C-terminus there is a catalytically inactive Rho-GAP-like domain. It shows homology to the Rho-GAP domain found in proteins that bind and stimulate the GTPase activity of the Rho family proteins. The two reasons why this domain has no GTPase stimulating activity are: the replacement of the catalytic Arg by His and absence of a helix.<ref name="role">PMID: 17765681</ref> The ASH-RhoGAP module mediates the interactions of OCRL1 with proteins that promote specific targeting to various cellular destinations such as early endosomes, Golgi complex, lysosomes and primary cilium.<ref name="Lowe and Dent">PMID: 28669993</ref> Since these two function as a single folding module, a destabilization in one of them will affect the stability of the other. <ref name="role"/> | At a region towards the C-terminus there is a catalytically inactive Rho-GAP-like domain. It shows homology to the Rho-GAP domain found in proteins that bind and stimulate the GTPase activity of the Rho family proteins. The two reasons why this domain has no GTPase stimulating activity are: the replacement of the catalytic Arg by His and absence of a helix.<ref name="role">PMID: 17765681</ref> The ASH-RhoGAP module mediates the interactions of OCRL1 with proteins that promote specific targeting to various cellular destinations such as early endosomes, Golgi complex, lysosomes and primary cilium.<ref name="Lowe and Dent">PMID: 28669993</ref> Since these two function as a single folding module, a destabilization in one of them will affect the stability of the other. <ref name="role"/> | ||
=== Function === | === Function === | ||
