Neurotrophin-4 (NFT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor.
Function
NFT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation.
Biological Processes
Positive regulation of neurotrophin TRK receptor signaling pathway:
NFT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NFT-4 binding.
Neuron projection morphogenesis:
Generating projection structures of a neuron,.
Ganglion mother cell fate determination, epidermis development, innervation
Nerve invading tissue and coming out
Disease
Relevance
Structural highlights
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