YKL 40: Difference between revisions

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== Function ==

<scene name='88/881548/Ykl-40/1'>YKL-40</scene> serves several biological functions. It catalyzes cell proliferation and growth. If YKL-40 is silenced, the proliferation of HEK293 and U87 decreases. Inversely, The expression of YKL-40 promotes the growth of fetal lung fibroblasts, epithelial cells, and chondrocytes found in the joints. It is able to promote this cell growth through Akt signaling and phosphorylation of MAPK. It also can increase smooth muscle cell proliferation and growth in humans with asthma. YKL-40 works hand in hand with IGF-1 (***scene) and promotes the growth of fibroblasts that are integral in tissue fibrosis. During tissue repair, YKL-40 is able to manage where smooth muscle cell is placed and where it sticks.

<scene name='88/881548/Ykl-40/1'>YKL-40</scene> serves several biological functions. It catalyzes cell proliferation and growth. If YKL-40 is silenced, the proliferation of HEK293 and U87 decreases. Inversely, The expression of YKL-40 promotes the growth of fetal lung fibroblasts, epithelial cells, and chondrocytes found in the joints. It is able to promote this cell growth through Akt signaling and phosphorylation of <scene name='88/881548/Mapk/1'>MAPK</scene>. It also can increase smooth muscle cell proliferation and growth in humans with asthma. YKL-40 works hand in hand with IGF-1 (***scene) and promotes the growth of fibroblasts that are integral in tissue fibrosis. During tissue repair, YKL-40 is able to manage where smooth muscle cell is placed and where it sticks.

YKL-40 also can protect cells from cell death. It is able to prevent cell apoptosis triggered by inflammatory reactions in the body. It is able to do this through PKB and AKT activation through phosphorylation, as well as inhibition of Fas expression, and Faim induction.

One of the most important roles YKL-40 play is in the immune system. It is used to differentiate and activate immune cells. They primarily control the differentiation of Th1 and Th2 using activated T cells. If CD4T+ cells do not have YKL-40, they differentiate into Th1 cells. This has a major impact on cytotoxic T lymphocyte expression which is important to increase anti-tumor immunity. YKL- 40 is expressed more when Th2 inflammatory responses are stimulated.

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@@ Line 9: / Line 9: @@
 == Function ==
-<scene name='88/881548/Ykl-40/1'>YKL-40</scene> serves several biological functions. It catalyzes cell proliferation and growth. If YKL-40 is silenced, the proliferation of HEK293 and U87 decreases. Inversely, The expression of YKL-40 promotes the growth of fetal lung fibroblasts, epithelial cells, and chondrocytes found in the joints. It is able to promote this cell growth through Akt signaling and phosphorylation of MAPK. It also can increase smooth muscle cell proliferation and growth in humans with asthma. YKL-40 works hand in hand with IGF-1 (***scene) and promotes the growth of fibroblasts that are integral in tissue fibrosis. During tissue repair, YKL-40 is able to manage where smooth muscle cell is placed and where it sticks.
+<scene name='88/881548/Ykl-40/1'>YKL-40</scene> serves several biological functions. It catalyzes cell proliferation and growth. If YKL-40 is silenced, the proliferation of HEK293 and U87 decreases. Inversely, The expression of YKL-40 promotes the growth of fetal lung fibroblasts, epithelial cells, and chondrocytes found in the joints. It is able to promote this cell growth through Akt signaling and phosphorylation of <scene name='88/881548/Mapk/1'>MAPK</scene>. It also can increase smooth muscle cell proliferation and growth in humans with asthma. YKL-40 works hand in hand with IGF-1 (***scene) and promotes the growth of fibroblasts that are integral in tissue fibrosis. During tissue repair, YKL-40 is able to manage where smooth muscle cell is placed and where it sticks.
 YKL-40 also can protect cells from cell death. It is able to prevent cell apoptosis triggered by inflammatory reactions in the body. It is able to do this through PKB and AKT activation through phosphorylation, as well as inhibition of Fas expression, and Faim induction.
 One of the most important roles YKL-40 play is in the immune system. It is used to differentiate and activate immune cells. They primarily control the differentiation of Th1 and Th2 using activated T cells. If CD4T+ cells do not have YKL-40, they differentiate into Th1 cells. This has a major impact on cytotoxic T lymphocyte expression which is important to increase anti-tumor immunity. YKL- 40 is expressed more when Th2 inflammatory responses are stimulated.