Postsynaptic density protein: Difference between revisions
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== Function == | == Function == | ||
PSD-95 is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse. This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective signaling molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream signaling proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane. | '''PSD-95''' is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse. This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective signaling molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream signaling proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane. | ||
With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort signaling complexes in the plasma membrane. | With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort signaling complexes in the plasma membrane. | ||
