6win: Difference between revisions

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<StructureSection load='6win' size='340' side='right'caption='[[6win]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='6win' size='340' side='right'caption='[[6win]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6win]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WIN FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WIN FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STY0300, t2586 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6win FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6win OCA], [https://pdbe.org/6win PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6win RCSB], [https://www.ebi.ac.uk/pdbsum/6win PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6win ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6win FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6win OCA], [https://pdbe.org/6win PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6win RCSB], [https://www.ebi.ac.uk/pdbsum/6win PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6win ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ticks transmit a diverse array of microbes to vertebrate hosts, including human pathogens, which has led to a human-centric focus in this vector system. Far less is known about pathogens of ticks themselves. Here, we discover that a toxin in blacklegged ticks (Ixodes scapularis) horizontally acquired from bacteria-called domesticated amidase effector 2 (dae2)-has evolved to kill mammalian skin microbes with remarkable efficiency. Secreted into the saliva and gut of ticks, Dae2 limits skin-associated staphylococci in ticks while feeding. In contrast, Dae2 has no intrinsic ability to kill Borrelia burgdorferi, the tick-borne Lyme disease bacterial pathogen. These findings suggest ticks resist their own pathogens while tolerating symbionts. Thus, just as tick symbionts can be pathogenic to humans, mammalian commensals can be harmful to ticks. Our study underscores how virulence is context-dependent and bolsters the idea that "pathogen" is a status and not an identity.
Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.,Hayes BM, Radkov AD, Yarza F, Flores S, Kim J, Zhao Z, Lexa KW, Marnin L, Biboy J, Bowcut V, Vollmer W, Pedra JHF, Chou S Cell. 2020 Dec 10;183(6):1562-1571.e12. doi: 10.1016/j.cell.2020.10.042. PMID:33306955<ref>PMID:33306955</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6win" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus typhi schroeter 1886]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chou, S]]
[[Category: Chou S]]
[[Category: Radkov, A D]]
[[Category: Radkov AD]]
[[Category: Amidase]]
[[Category: Antimicrobial protein]]
[[Category: Peptidoglycan hydrolase]]
[[Category: Toxin]]

Latest revision as of 10:38, 23 October 2024

Type 6 secretion amidase effector 2 (Tae2)

6win, resolution 2.05Å

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