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==Solution structure of Pi4, a four disulfide bridged scorpion toxin active on potassium channels==
==Solution structure of Pi4, a four disulfide bridged scorpion toxin active on potassium channels==
<StructureSection load='1n8m' size='340' side='right'caption='[[1n8m]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1n8m' size='340' side='right'caption='[[1n8m]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1n8m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8M FirstGlance]. <br>
<table><tr><td colspan='2'>[[1n8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8M FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8m OCA], [https://pdbe.org/1n8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8m RCSB], [https://www.ebi.ac.uk/pdbsum/1n8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8m ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8m OCA], [https://pdbe.org/1n8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8m RCSB], [https://www.ebi.ac.uk/pdbsum/1n8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KAX64_PANIM KAX64_PANIM]] Potently, completely and reversibly blocks voltage-gated potassium channel Kv1.2/KCNA2 and Shaker B (Sh). Also blocks small conductance (SK) calcium-activated potassium channel (KCNN).<ref>PMID:12919322</ref>
[https://www.uniprot.org/uniprot/KAX64_PANIM KAX64_PANIM] Potently, completely and reversibly blocks voltage-gated potassium channel Kv1.2/KCNA2 and Shaker B (Sh). Also blocks small conductance (SK) calcium-activated potassium channel (KCNN).<ref>PMID:12919322</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barek, S M]]
[[Category: Pandinus imperator]]
[[Category: Delepierre, M]]
[[Category: Delepierre M]]
[[Category: Garnier, D]]
[[Category: Garnier D]]
[[Category: Gomez-Lagunas, F]]
[[Category: Gomez-Lagunas F]]
[[Category: Guijarro, J I]]
[[Category: Guijarro JI]]
[[Category: Olamendi-Portugal, T]]
[[Category: M'Barek S]]
[[Category: Possani, L D]]
[[Category: Olamendi-Portugal T]]
[[Category: Rochat, H]]
[[Category: Possani LD]]
[[Category: Sabatier, J M]]
[[Category: Rochat H]]
[[Category: Disulfide bridge stabilized alpha beta motif]]
[[Category: Sabatier JM]]
[[Category: Potassium channel blocker]]
[[Category: Toxin]]
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