2lm0: Difference between revisions
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==Solution structure of the AF4-AF9 complex== | ==Solution structure of the AF4-AF9 complex== | ||
<StructureSection load='2lm0' size='340' side='right'caption='[[2lm0 | <StructureSection load='2lm0' size='340' side='right'caption='[[2lm0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2lm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LM0 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm0 OCA], [https://pdbe.org/2lm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm0 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm0 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm0 OCA], [https://pdbe.org/2lm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm0 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/AFF1_HUMAN AFF1_HUMAN] Precursor B-cell acute lymphoblastic leukemia. A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AFF1_HUMAN AFF1_HUMAN] [https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bushweller | [[Category: Bushweller JH]] | ||
[[Category: Cierpicki | [[Category: Cierpicki T]] | ||
[[Category: Johnson | [[Category: Johnson SA]] | ||
[[Category: Kuntimaddi | [[Category: Kuntimaddi A]] | ||
[[Category: Leach | [[Category: Leach BI]] | ||
[[Category: Schmidt | [[Category: Schmidt CR]] | ||
