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==Solution NMR Structure of Lysine-specific demethylase lid from Drosophila melanogaster, Northeast Structural Genomics Consortium Target FR824D==
==Solution NMR Structure of Lysine-specific demethylase lid from Drosophila melanogaster, Northeast Structural Genomics Consortium Target FR824D==
<StructureSection load='2lm1' size='340' side='right'caption='[[2lm1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lm1' size='340' side='right'caption='[[2lm1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LM1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LM1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG9088, lid ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm1 OCA], [https://pdbe.org/2lm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm1 OCA], [https://pdbe.org/2lm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>
[https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Acton TB]]
[[Category: CEBS, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes]]
[[Category: Everett JK]]
[[Category: Everett, J K]]
[[Category: Kohan E]]
[[Category: Kohan, E]]
[[Category: Kusch T]]
[[Category: Kusch, T]]
[[Category: Lee D]]
[[Category: Lee, D]]
[[Category: Mills JL]]
[[Category: Mills, J L]]
[[Category: Montelione GT]]
[[Category: Montelione, G T]]
[[Category: Sahdev S]]
[[Category: Structural genomic]]
[[Category: Szyperski T]]
[[Category: Sahdev, S]]
[[Category: Xiao R]]
[[Category: Szyperski, T]]
[[Category: Xiao, R]]
[[Category: Ceb]]
[[Category: Chaperone-enabled studies of epigenetic regulation enzyme]]
[[Category: Dna binding protein]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
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